Abstract
Angiotensin-converting enzyme 2 (ACE2) has been identified as the host entry receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the COVID-19 pandemic. ACE2 is a regulatory enzyme of the renin-angiotensin system and has protective functions in many cardiovascular, pulmonary and metabolic diseases. This review summarizes available murine models with systemic or organ-specific deletion of ACE2, or with overexpression of murine or human ACE2. The purpose of this review is to provide researchers with the genetic tools available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathogenesis and treatment of COVID-19.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Angiotensin-Converting Enzyme 2
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Animals
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Betacoronavirus / physiology
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COVID-19
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / pathology*
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Coronavirus Infections / metabolism
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Coronavirus Infections / pathology
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Coronavirus Infections / virology
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Disease Models, Animal*
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Humans
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Lung Diseases / metabolism
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Lung Diseases / pathology*
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Metabolic Diseases / metabolism
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Metabolic Diseases / pathology
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Mice
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Mice, Mutant Strains
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Pandemics
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Peptidyl-Dipeptidase A / genetics
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Peptidyl-Dipeptidase A / metabolism*
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Pneumonia, Viral / metabolism
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Pneumonia, Viral / pathology
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Pneumonia, Viral / virology
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SARS-CoV-2
Substances
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Peptidyl-Dipeptidase A
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ACE2 protein, human
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Ace2 protein, mouse
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Angiotensin-Converting Enzyme 2