Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants

Front Immunol. 2020 Sep 25:11:511513. doi: 10.3389/fimmu.2020.511513. eCollection 2020.

Abstract

Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.

Keywords: NF-κB; adjuvants; capsaicin; honokiol; vaccines.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adjuvants, Immunologic* / chemistry
  • Adjuvants, Immunologic* / pharmacology
  • Animals
  • Biphenyl Compounds* / chemistry
  • Biphenyl Compounds* / pharmacology
  • Lignans* / chemistry
  • Lignans* / pharmacology
  • Mice
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / immunology
  • RAW 264.7 Cells
  • Vaccines / chemistry
  • Vaccines / immunology

Substances

  • Adjuvants, Immunologic
  • Biphenyl Compounds
  • Lignans
  • NF-kappa B
  • Vaccines
  • honokiol