Extracorporeal shockwave treatment in knee osteoarthritis: therapeutic effects and possible mechanism

Biosci Rep. 2020 Nov 27;40(11):BSR20200926. doi: 10.1042/BSR20200926.

Abstract

Osteoarthritis (OA), the most common degenerative joint disease, is characterized by the cardinal symptoms of chronic pain and restricted joint activity. The complicated pathological changes associated with OA and unclear mechanistic etiology have rendered existing non-surgical OA management options unsatisfactory. Increasing clinical and experimental evidence suggests that extracorporeal shockwave therapy (ESWT) is beneficial in OA treatment. ESWT is found to have modifying effects on cartilage and subchondral bone alterations in OA progression, as well as the clinical complaints of patients, including chronic pain and limited joint activities. However, the specific treatment strategy regarding the dosage and frequency of ESWT is still underdetermined. This review discusses the existing evidence regarding the therapeutic indications and possible mechanism of ESWT for OA treatment.

Keywords: extracorporeal shockwave; osteoarthritis; pain; subchondral bone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arthralgia / diagnosis
  • Arthralgia / physiopathology
  • Arthralgia / therapy*
  • Biomechanical Phenomena
  • Extracorporeal Shockwave Therapy* / adverse effects
  • Humans
  • Knee Joint / pathology
  • Knee Joint / physiopathology*
  • Osteoarthritis, Knee / diagnosis
  • Osteoarthritis, Knee / physiopathology
  • Osteoarthritis, Knee / therapy*
  • Range of Motion, Articular
  • Recovery of Function
  • Treatment Outcome