Immune responses in genomically simple SWI/SNF-deficient cancers

Cancer. 2021 Jan 15;127(2):172-180. doi: 10.1002/cncr.33172. Epub 2020 Oct 20.
No abstract available

Keywords: SWI/SNF; endogenous retrovirus; immune checkpoint blockade; immunotherapy; tumor immunology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Combined Modality Therapy / methods
  • DNA Helicases / deficiency*
  • DNA Helicases / genetics*
  • DNA-Binding Proteins / deficiency*
  • DNA-Binding Proteins / genetics*
  • Disease Models, Animal
  • Humans
  • Immune Checkpoint Inhibitors / therapeutic use
  • Immunity*
  • Mice
  • Mutation
  • Neoplasms / drug therapy
  • Neoplasms / immunology*
  • Neoplasms / metabolism*
  • Neoplasms / radiotherapy
  • Nuclear Proteins / deficiency*
  • Nuclear Proteins / genetics*
  • Polymorphism, Single Nucleotide
  • SMARCB1 Protein / deficiency*
  • SMARCB1 Protein / genetics*
  • Transcription Factors / deficiency*
  • Transcription Factors / genetics*
  • Treatment Outcome

Substances

  • DNA-Binding Proteins
  • Immune Checkpoint Inhibitors
  • Nuclear Proteins
  • PBRM1 protein, human
  • SMARCB1 Protein
  • SMARCB1 protein, human
  • Transcription Factors
  • SMARCA4 protein, human
  • DNA Helicases