Specific Redistribution of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Respiratory System and Intestinal Tract

Pengcheng Du; Chuan Song; Rui Li; Yangzi Song; Jiarui Li; Nan Ding; Ju Zhang; Rui Song; Junyan Han; Guiju Gao; Jinglin Yue; Ang Duan; Yanyi Huang; Jing An; Jianbin Wang; Fujie Zhang; Chen Chen; Hui Zeng

doi:10.1093/cid/ciaa1617

Specific Redistribution of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Respiratory System and Intestinal Tract

Clin Infect Dis. 2021 Nov 2;73(9):e2814-e2817. doi: 10.1093/cid/ciaa1617.

Authors

Pengcheng Du^{1

2}, Chuan Song^{1

2}, Rui Li^{1

2}, Yangzi Song^{1

2}, Jiarui Li^{1

2}, Nan Ding^{1

2}, Ju Zhang^{1

2}, Rui Song³, Junyan Han^{1

2}, Guiju Gao³, Jinglin Yue^{1

2}, Ang Duan^{1

2}, Yanyi Huang⁴, Jing An⁵, Jianbin Wang⁶, Fujie Zhang³, Chen Chen^{1

2}, Hui Zeng^{1

2}

Affiliations

¹ Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
² Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People's Republic of China.
³ Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
⁴ Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, People's Republic of China.
⁵ Department of Microbiology, School of Basic Medical Science, Capital Medical University, Beijing, People's Republic of China.
⁶ School of Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Chinese Institute for Brain Research, Tsinghua University, Beijing, People's Republic of China.

Abstract

Intrahost analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic sequences identified 2 viral haplotypes comprised of 3 genetically linked mutations from the respiratory and intestinal tracts of a patient with coronavirus disease 2019. Spatiotemporal data suggest that this patient initially had dual infection of 2 SARS-CoV-2 variants, which subsequently redistributed into the 2 systems.

Keywords: SARS-CoV-2; dual infection; organ-specific redistribution; severe acute respiratory syndrome coronavirus 2.

MeSH terms

COVID-19*
Genomics
Humans
Respiratory System
SARS-CoV-2*