ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) Expression and Localization of SARS-CoV-2 Infection in the Human Heart

Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):542-544. doi: 10.1161/ATVBAHA.120.315229. Epub 2020 Oct 22.

Authors

Atsushi Sakamoto^#¹, Rika Kawakami^#¹, Kenji Kawai^#¹, Andrea Gianatti², Dario Pellegrini², Robert Kutys¹, Liang Guo¹, Masayuki Mori¹, Anne Cornelissen¹, Yu Sato¹, Antonio Bellasi², Lara Faggi², Charles Hong³, Maria Romero¹, Giulio Guagliumi², Renu Virmani¹, Aloke V Finn^{1

3}

Affiliations

¹ CVPath Institute, Inc, Gaithersburg, MD (A.S., R. Kawakami, K.K., R. Kutys, L.G., M.M., A.C., Y.S., M.R., R.V., A.V.F.).
² Ospedale Papa Giovanni XXIII Hospital, Bergamo, Italy (A.G., D.P., A.B., L.F., G.G.).
³ University of Maryland, Baltimore (C.H., A.V.F.).

^# Contributed equally.

PMID: 33086866
DOI: 10.1161/ATVBAHA.120.315229

No abstract available

Keywords: COVID-19; SARS-CoV-2; cardiovascular disease; heart.

Publication types

Review

MeSH terms

Angiotensin-Converting Enzyme 2 / biosynthesis
Angiotensin-Converting Enzyme 2 / genetics*
COVID-19 / epidemiology
COVID-19 / metabolism*
Gene Expression Regulation*
Humans
Myocardium / metabolism*
Pandemics
RNA / genetics*
SARS-CoV-2*
Serine Endopeptidases / biosynthesis
Serine Endopeptidases / genetics*

Substances

RNA
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, human