Therapy-related B-cell acute lymphoblastic leukemia in adults has unique genetic profile with frequent loss of TP53 and inferior outcome
Leukemia
.
2021 Jul;35(7):2097-2101.
doi: 10.1038/s41375-020-01061-9.
Epub 2020 Oct 21.
Authors
Liron Barnea Slonim
1
,
Juehua Gao
1
,
Madelyn Burkart
2
,
Oluwatobi E Odetola
3
,
Masha Kocherginsky
4
,
Shira N Dinner
2
,
Xinyan Lu
1
,
Firas Wehbe
1
2
3
4
,
Lawrence Jennings
1
,
Jessica K Altman
2
,
Kamran M Mirza
3
,
Yi-Hua Chen
1
,
Madina Sukhanova
5
Affiliations
1
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
2
Department of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
3
Department of Pathology and Laboratory Medicine and Medical Education, Loyola University Chicago Stritch School of Medicine, Chicago, IL, USA.
4
Department of Preventive Medicine (Health and Biomedical Informatics), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
5
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[email protected]
.
PMID:
33087830
DOI:
10.1038/s41375-020-01061-9
No abstract available
MeSH terms
Adult
B-Lymphocytes / physiology*
Genetic Profile
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Tumor Suppressor Protein p53 / genetics*
Substances
TP53 protein, human
Tumor Suppressor Protein p53