RIFM fragrance ingredient safety assessment, carbonic acid, 2-hydroxyethyl 5-methyl-2-(1-methylethyl)cyclohexyl ester, CAS registry number 156679-39-9

A M Api; D Belsito; S Biserta; D Botelho; M Bruze; G A Burton Jr; J Buschmann; M A Cancellieri; M L Dagli; M Date; W Dekant; C Deodhar; A D Fryer; S Gadhia; L Jones; K Joshi; M Kumar; A Lapczynski; M Lavelle; I Lee; D C Liebler; H Moustakas; M Na; T M Penning; G Ritacco; J Romine; N Sadekar; T W Schultz; D Selechnik; F Siddiqi; I G Sipes; G Sullivan; Y Thakkar; Y Tokura

doi:10.1016/j.fct.2020.111822

RIFM fragrance ingredient safety assessment, carbonic acid, 2-hydroxyethyl 5-methyl-2-(1-methylethyl)cyclohexyl ester, CAS registry number 156679-39-9

Food Chem Toxicol. 2020 Dec 15:146 Suppl 1:111822. doi: 10.1016/j.fct.2020.111822. Epub 2020 Oct 19.

Authors

A M Api¹, D Belsito², S Biserta¹, D Botelho¹, M Bruze³, G A Burton Jr⁴, J Buschmann⁵, M A Cancellieri¹, M L Dagli⁶, M Date¹, W Dekant⁷, C Deodhar¹, A D Fryer⁸, S Gadhia¹, L Jones¹, K Joshi¹, M Kumar¹, A Lapczynski¹, M Lavelle¹, I Lee¹, D C Liebler⁹, H Moustakas¹, M Na¹, T M Penning¹⁰, G Ritacco¹, J Romine¹, N Sadekar¹, T W Schultz¹¹, D Selechnik¹, F Siddiqi¹, I G Sipes¹², G Sullivan¹³, Y Thakkar¹, Y Tokura¹⁴

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
² Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
³ Member Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE, 20502, Sweden.
⁴ Member Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
⁵ Member Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany.
⁶ Member Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁷ Member Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.
⁸ Member Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
⁹ Member Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.
¹⁰ Member of Expert Panel, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.
¹¹ Member Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA.
¹² Member Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
¹³ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: [email protected].
¹⁴ Member Expert Panel, The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

PMID: 33091557
DOI: 10.1016/j.fct.2020.111822

No abstract available

Keywords: Developmental, and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization.

Publication types

Review

MeSH terms

Animals
Bacteria / drug effects
Consumer Product Safety
Endpoint Determination
Humans
Menthol / analogs & derivatives*
Menthol / toxicity*
No-Observed-Adverse-Effect Level
Odorants*
Perfume / toxicity*
Risk Assessment

Substances

Perfume
Menthol