Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro

Nicola Clementi; Carolina Scagnolari; Antonella D'Amore; Fioretta Palombi; Elena Criscuolo; Federica Frasca; Alessandra Pierangeli; Nicasio Mancini; Guido Antonelli; Massimo Clementi; Armando Carpaneto; Antonio Filippini

doi:10.1016/j.phrs.2020.105255

Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro

Pharmacol Res. 2021 Jan:163:105255. doi: 10.1016/j.phrs.2020.105255. Epub 2020 Oct 20.

Affiliations

¹ Laboratory of Medical Microbiology and Virology at "Vita-Salute" San Raffaele University, Milan, 20132 Italy; Laboratory of Medical Microbiology and Virology, IRCCS San Raffaele Hospital, Milan, 20132 Italy.
² Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia, SAPIENZA University of Rome, Rome, Italy.
³ Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, SAPIENZA University of Rome, 16 Via A. Scarpa, Rome, 00161 Italy.
⁴ Laboratory of Medical Microbiology and Virology at "Vita-Salute" San Raffaele University, Milan, 20132 Italy.
⁵ Laboratory of Medical Microbiology and Virology at "Vita-Salute" San Raffaele University, Milan, 20132 Italy; Laboratory of Medical Microbiology and Virology, IRCCS San Raffaele Hospital, Milan, 20132, Italy.
⁶ Department of Earth, Environment and Life Sciences (DISTAV) - University of Genoa, Viale Benedetto XV 5, Genova, 16132 Italy; Institute of Biophysics, National Research Council, Via De Marini 6, Genoa, 16149 Italy.

Abstract

Schematic representation of TPC2 role, investigated through genetic ablation and drug blocker, in the inhibition of Coronaviruses release into the cells.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

COVID-19*
Flavanones* / pharmacology
Humans
Pharmaceutical Preparations*
SARS-CoV-2

Substances

Flavanones
Pharmaceutical Preparations
naringenin