Langerhans cell histiocytosis (LCH) is rare during the newborn period. The term is used to describe a disorder characterized by infiltration of Langerhans cells into various organs. Langerhans cells are derived from the bone marrow, and are a type of dendritic cells found primarily in the epidermis. LCH may involve multiple organ systems, the most common being the skin and the bones. Cutaneous involvement is very common in LCH, and is often the presenting symptom. The most classic presentation is that of seborrheic dermatitis like eruption. Papules, petechiae, erosions and vesicles were also described. In our present case we describe a neonate with vesiculopustular rash appearing immediately after birth with an unexpected diagnosis made by skin biopsy.