Room-Temperature Synthesis of Tetrasubstituted 1,3-Dithioles by Dimerizing Sulfuration of Chalcones with Elemental Sulfur

Thanh Binh Nguyen; Dinh Hung Mac; Pascal Retailleau

doi:10.1021/acs.joc.0c01618

Room-Temperature Synthesis of Tetrasubstituted 1,3-Dithioles by Dimerizing Sulfuration of Chalcones with Elemental Sulfur

J Org Chem. 2020 Nov 6;85(21):13508-13516. doi: 10.1021/acs.joc.0c01618. Epub 2020 Oct 27.

Authors

Thanh Binh Nguyen¹, Dinh Hung Mac², Pascal Retailleau¹

Affiliations

¹ Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
² Faculty of Chemistry, VNU University of Science, Vietnam National University in Hanoi, 19 Le Thanh Tong, Hanoi , Viet Nam.

PMID: 33108186
DOI: 10.1021/acs.joc.0c01618

Abstract

Chalcones were found to undergo sulfurative dimerization with elemental sulfur to tetrasubstituted 1,3-dithioles. The reaction was found to proceed at room temperature in the presence of a nitrogen-base catalyst in DMSO.