Antimycotic action of alkyl derivatives of 5-(benzenesulfonamide)-1,2,3,4-tetrahydro-2-thioxo-4-pyrimidinon e

Farmaco Sci. 1987 Aug;42(8):611-8.

Abstract

Several series of mono-, di- and trimethyl derivatives of N-(6-amino-1,2,3,4-tetrahydro-4-oxo-2-thioxo-5-pyrimidinyl)benzene sulfonamide substituted at the benzene ring (Z), were synthesized and studied spectrophotometrically. The spectral and physical data enabled the structures of the methyl derivatives obtained by methylating (Z) to be identified. When assayed biologically as antimycotics, a small percentage of the substances exhibited mild fungicide activity.

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Candida / drug effects
  • Candida albicans / drug effects
  • Chemical Phenomena
  • Chemistry
  • Microbial Sensitivity Tests
  • Pyrimidinones / chemical synthesis*
  • Pyrimidinones / pharmacology
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / pharmacology

Substances

  • Antifungal Agents
  • Pyrimidinones
  • Sulfonamides