[Anaplastic lymphoma kinase-positive large B-cell lymphoma in a child]

Zhonghua Er Ke Za Zhi. 2020 Nov 2;58(11):937-939. doi: 10.3760/cma.j.cn112140-20200403-00349.
[Article in Chinese]

Abstract

1例11岁男童因“骨痛4个月余、发热伴淋巴结肿大3个月余”就诊,影像提示全身多部位占位性病变伴多发骨破坏,头皮肿物活检病理示OCT-2、BOB1、间变性淋巴瘤激酶(ALK)阳性(胞质颗粒状阳性),CD30阴性,并检测到CLTC-ALK融合基因,诊断为ALK阳性大B细胞淋巴瘤,按改良LMB89高危方案化疗达到完全缓解后行自体造血干细胞移植,移植后45 d因重症肺炎伴发呼吸衰竭死亡。该病儿童罕见,起病隐匿,进展迅速,病理以表达ALK但不表达CD30为特征,治疗以高强度化疗加自体造血干细胞移植为主,预后不佳。.

Publication types

  • Case Reports

MeSH terms

  • Anaplastic Lymphoma Kinase* / genetics
  • Child
  • Family
  • Humans
  • Lymphoma, Large B-Cell, Diffuse*
  • Lymphoma, Large-Cell, Anaplastic*

Substances

  • Anaplastic Lymphoma Kinase