Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy

Pei-Feng Liu; Ammad Ahmad Farooqi; Sheng-Yao Peng; Tzu-Jung Yu; Hans-Uwe Dahms; Cheng-Hsin Lee; Jen-Yang Tang; Sheng-Chieh Wang; Chih-Wen Shu; Hsueh-Wei Chang

doi:10.1016/j.semcancer.2020.10.009

Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy

Semin Cancer Biol. 2022 Aug:83:269-282. doi: 10.1016/j.semcancer.2020.10.009. Epub 2020 Oct 27.

Authors

Affiliations

¹ Department of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: [email protected].
² Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Electronic address: [email protected].
³ Department of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: [email protected].
⁴ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: [email protected].
⁵ Department of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan. Electronic address: [email protected].
⁶ Department of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: [email protected].
⁷ Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: [email protected].
⁸ Department of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: [email protected].
⁹ Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan; Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: [email protected].
¹⁰ Department of Biomedical Science and Environmental Biology, PhD Program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: [email protected].

PMID: 33127466
DOI: 10.1016/j.semcancer.2020.10.009

Abstract

Noncoding RNAs (ncRNAs) regulation of various diseases including cancer has been extensively studied. Reactive oxidative species (ROS) elevated by oxidative stress are associated with cancer progression and drug resistance, while autophagy serves as an ROS scavenger in cancer cells. However, the regulatory effects of ncRNAs on autophagy and ROS in various cancer cells remains complex. Here, we explore how currently investigated ncRNAs, mainly miRNAs and lncRNAs, are involved in ROS production through modulating antioxidant genes. The regulatory effects of miRNAs and lncRNAs on autophagy-related (ATG) proteins to control autophagy activity in cancer cells are discussed. Moreover, differential expression of ncRNAs in tumor and normal tissues of cancer patients are further analyzed using The Cancer Genome Atlas (TCGA) database. This review hypothesizes links between ATG genes- or antioxidant genes-modulated ncRNAs and ROS production, which might result in tumorigenesis, malignancy, and cancer recurrence. A better understanding of the regulation of ROS and autophagy by ncRNAs might advance the use of ncRNAs as diagnostic and prognostic markers as well as therapeutic targets in cancer therapy.

Keywords: Autophagy; Cancer; Diagnostic marker; Noncoding RNA; Oxidative stress; Therapeutic marker.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / metabolism
Autophagy / genetics
Humans
MicroRNAs* / genetics
Neoplasm Recurrence, Local
Neoplasms* / genetics
Neoplasms* / therapy
Oxidative Stress* / genetics
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics
Reactive Oxygen Species / metabolism

Substances

Antioxidants
MicroRNAs
RNA, Long Noncoding
RNA, Untranslated
Reactive Oxygen Species