Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host: An Update

Donald Dumford 3rd; Marion J Skalweit

doi:10.1016/j.idc.2020.08.005

Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host: An Update

Infect Dis Clin North Am. 2020 Dec;34(4):821-847. doi: 10.1016/j.idc.2020.08.005.

Authors

Donald Dumford 3rd¹, Marion J Skalweit²

Affiliations

¹ Department of Medicine, Northeast Ohio Medical University, 4209 St. Rt. 44, PO Box 95, Rootstown, OH 44272, USA; Division of Infectious Diseases, Cleveland Clinic Akron General, 224 West Exchange Street, Suite 290, Akron, OH 44302, USA. Electronic address: [email protected].
² Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA; Louis Stokes Cleveland Department of Veterans Affairs, 10701 East Boulevard 111 (W), Cleveland, OH 44106, USA.

PMID: 33131573
DOI: 10.1016/j.idc.2020.08.005

Abstract

This article reviews antibiotic resistance and treatment of bacterial infections in the growing number of patients who are immunocompromised: solid organ transplant recipients, the neutropenic host, and persons with human immunodeficiency virus and AIDS. Specific mechanisms of resistance in both gram-negative and gram-positive bacteria, as well as newer treatment options are addressed elsewhere and are only briefly discussed in the context of the immunocompromised host.

Keywords: HIV/AIDS; Immunocompromise; Infection; MDRO; Neutropenic host; Organ transplant recipient.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis
Bacterial Infections / drug therapy*
Bacterial Infections / microbiology
Drug Resistance, Multiple, Bacterial / drug effects
Humans
Immunocompromised Host*
Inappropriate Prescribing

Substances

Anti-Bacterial Agents