A new flavanone derivative from the rhizomes of Boesenbergia pandurata

Nat Prod Res. 2022 Apr;36(8):1959-1965. doi: 10.1080/14786419.2020.1837822. Epub 2020 Nov 3.

Abstract

From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2-5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC50 value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC50, 0.83 µM).

Keywords: Boesenbergia pandurata; PANC-1; cytotoxicity; flavanone.

MeSH terms

  • Antineoplastic Agents, Phytogenic* / chemistry
  • Cell Line, Tumor
  • Flavanones* / analysis
  • Flavanones* / pharmacology
  • Humans
  • Rhizome / chemistry
  • Zingiberaceae* / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavanones