Whole-Body MRI with an Ultrahigh b-Value of 2000 s/mm² Improves the Specificity of Diffusion-Weighted Imaging in Patients with Plasma Cell Dyscrasias

Rationale and objectives: Our study compared sensitivity, specificity, and accuracy of whole-body diffusion-weighted imaging (WB-DWI) using a b-value of 2000 s/mm² with that of the commonly used b-value of 800 s/mm² for depiction of active tumor sites in patients with plasma cell diseases. We introduced an ultrahigh b-value to reduce interfering signals from benign and post-therapeutic inactive lesions by suppressing T2-shine-through effects.

Materials and methods: The prospective single-center study included patients when they went through a whole-body MRI (WB-MRI) staging or response evaluation procedure. The apparent diffusion coefficient (ADC) and morphologic appearance served as reference for classifying focal lesions on WB-DWI as vital or post-therapeutic. Additionally, we compared our classification with patients' serological markers of disease activity.

Results: One hundred participants (65 ± 10 years, 58 men) underwent WB-DWI between June and October 2019. The detection rate of vital focal lesions was similar for both b-values with a sensitivity of 0.99 using b = 800 s/mm² and 0.98 using b = 2000 s/mm². By contrast, specificity and accuracy were 0.09 and 0.71 when using a b-value of 800 s/mm², and 0.96 and 0.98 when using a b-value of 2000 s/mm², respectively. The difference in specificity and accuracy was statistically significant (p < 0.001).

Conclusion: Using a b-value of 2000 s/mm² significantly improved the specificity of lesion detection with WB-DWI as compared to the commonly used b-value of 800 s/mm². The high b-value significantly reduced signal intensities of post-therapeutic or benign lesions and provided a significantly more accurate representation of active tumor load.