MicroRNA155 Expression in Different Phenotypes and Genotypes of Behçet's Disease in a Sample of Egyptian Patients

Sally S Hassouna; Manal Y Tayel; Ashraf I Alzawawy; Dalal M Elkaffash; Ahmed M Abdel Hadi; Eman H Elsayed; Rowayda M Amin; Eman Tayae; Alya Elkayal; Asmaa Nasr

doi:10.31138/mjr.31.3.337

MicroRNA155 Expression in Different Phenotypes and Genotypes of Behçet's Disease in a Sample of Egyptian Patients

Mediterr J Rheumatol. 2020 Sep 30;31(3):337-340. doi: 10.31138/mjr.31.3.337. eCollection 2020 Sep.

Affiliations

¹ Internal Medicine Department, Rheumatology and Immunology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
² Clinical and Chemical Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
³ Opthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Abstract

Aim: To display microRNA155 (miRNA155) expression in different entities of Behçet's disease (BD), and to find out if expression is affected in more than one of disease status than another, either phenotypically, according to HLA B51 expression, presence of family history, or patients' age.

Methods: Thirty BD patients (13 of which were HLAB51 positive) and 15 healthy subjects' samples were obtained. White blood cell miRNA155 expression in both types of samples was estimated.

Results: Results showed that there is a degree of relation between decrease of miRNA155 expression and different disease aspects, and also, that miRNA155 has an inverse relation with the patients' ages.

Conclusion: MiRNA155 might be used as a measure of disease of different phenotypes, and that any manifestation of the disease can happen when the expression level decreases.

Keywords: Behçet’s; microRNA155; phenotypes.