The chicken B cell compartment

Science. 1987 Nov 20;238(4830):1094-8. doi: 10.1126/science.3317827.

Abstract

A very unusual molecular mechanism is involved in generating the preimmune repertoire in the chicken bursa of Fabricius. A unique rearranged V gene is diversified through a program of segmental gene conversion with a pool of noncoding pseudogenes being used as donors. A specifically committed progenitor that originates in the embryonic bursa is responsible for long-term maintenance of the B cell population. Both these properties and the characteristics of the peripheral B cell compartment are discussed in terms of the evolution of the T and B immune systems.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Diversity
  • B-Lymphocytes / immunology*
  • Bursa of Fabricius / embryology
  • Bursa of Fabricius / immunology*
  • Chickens / immunology*
  • Genes, Immunoglobulin*
  • Immunoglobulin Variable Region / genetics
  • Immunoglobulins / genetics*

Substances

  • Immunoglobulin Variable Region
  • Immunoglobulins