Failure of high dose mebendazole as a microfilaricide in patients with loiasis

G D Burchard; P Kern

doi:10.1016/0035-9203(87)90156-8

Failure of high dose mebendazole as a microfilaricide in patients with loiasis

Trans R Soc Trop Med Hyg. 1987;81(3):420. doi: 10.1016/0035-9203(87)90156-8.

Authors

G D Burchard¹, P Kern

Affiliation

¹ Laboratoire de Recherches, Albert Schweitzer Hospital, Lambarene, Gabon.

PMID: 3318018
DOI: 10.1016/0035-9203(87)90156-8

Abstract

The effectiveness of mebendazole as a microfilaricide in patients with loiasis was studied. The drug regimen was 1 g twice daily for 21 days in adults. During and after treatment, the microfilarial density was unchanged. Therefore, mebendazole has no direct effect on the microfilarial density of Loa loa.

Publication types

Clinical Trial

MeSH terms

Clinical Trials as Topic
Filariasis / drug therapy*
Humans
Loiasis / drug therapy*
Mebendazole / administration & dosage
Mebendazole / therapeutic use*

Substances

Mebendazole