A knockout combination for MPN stem cells

Megan Bywater; Steven W Lane

doi:10.1084/jem.20201884

A knockout combination for MPN stem cells

J Exp Med. 2021 Feb 1;218(2):e20201884. doi: 10.1084/jem.20201884.

Authors

Megan Bywater^{1

2}, Steven W Lane^{1

2

3}

Affiliations

¹ Cancer Program, QIMR Berghofer Medical Research Institute, Herston, Australia.
² University of Queensland, Brisbane, Australia.
³ Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Australia.

Abstract

Myeloproliferative neoplasms (MPNs) are a group of blood cancers that are maintained by stem cell populations. In this issue of JEM, Dagher et al. (https://doi.org/10.1084/jem.20201268) combine arsenic and interferon α to deliver a knockout punch to MPN stem cells and provide new hope to cure patients with MPNs.

Publication types

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MeSH terms

Antiviral Agents
Hematologic Neoplasms*
Humans
Myeloproliferative Disorders*
Stem Cells

Substances

Antiviral Agents