Abstract
The presence of anti-Ro (SS-A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti-Ro (SS-A) antibodies in an indirect immunofluorescence assay, Ro (SS-A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS-A) antigen, anti-Ro (SS-A) antibody, and heart block is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Autoantigens / analysis*
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Autoantigens / immunology
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Cholinesterases / metabolism
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Fetal Heart / immunology
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Fetal Heart / pathology*
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Fluorescent Antibody Technique
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Gestational Age
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Heart Block / immunology*
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Heart Conduction System / immunology
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Heart Conduction System / pathology*
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Humans
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Immune Sera / analysis
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RNA, Small Cytoplasmic*
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Ribonucleoproteins*
Substances
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Autoantigens
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Immune Sera
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoproteins
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SS-A antigen
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Cholinesterases