Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Affiliations

• ¹ Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands. [email protected].
• ² Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
• ³ Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
• ⁴ Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
• ⁵ l'institut du thorax Université de Nantes, CHU Nantes, INSERM, CNRS, Nantes, France.
• ⁶ CHU Nantes, Department of Neuroradiology, Nantes, France.
• ⁷ Stroke Research Centre, University College London Queen Square Institute of Neurology, London, UK.
• ⁸ Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
• ⁹ Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
• ¹⁰ Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
• ¹¹ Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
• ¹² Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
• ¹³ Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
• ¹⁴ Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
• ¹⁵ Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• ¹⁶ Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
• ¹⁷ Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China.
• ¹⁸ Montréal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
• ¹⁹ Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC, Canada.
• ²⁰ Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
• ²¹ UK Biobank, Cheadle, Stockport, UK.
• ²² Neurogenetics Laboratory, The National Hospital of Neurology and Neurosurgery, London, UK.
• ²³ Pediatric Radiology, Necker Hospital for Sick Children, Université Paris Descartes, Paris, France.
• ²⁴ Department of Neuroradiology, Sainte-Anne Hospital and Université Paris Descartes, INSERM UMR, S894, Paris, France.
• ²⁵ Department of Neuroradiology, University Hospital of Brest, Brest, France.
• ²⁶ Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
• ²⁷ Department of Neuroradiology, University Hospital of Rennes, Rennes, France.
• ²⁸ Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
• ²⁹ K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• ³⁰ Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
• ³¹ Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
• ³² Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• ³³ The Cancer Clinic, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
• ³⁴ Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
• ³⁵ HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• ³⁶ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
• ³⁷ National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
• ³⁸ Dortmund University of Applied Science and Arts, Dortmund, Germany.
• ³⁹ Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany.
• ⁴⁰ Zurich University of Applied Sciences, School of Life Sciences and Facility Management, Zurich, Switzerland.
• ⁴¹ SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
• ⁴² Department of Surgery, University of Otago, Dunedin, New Zealand.
• ⁴³ Department of Cardiovascular Sciences and National Institute for Health Research, University of Leicester, Leicester, UK.
• ⁴⁴ Leicester Biomedical Research Centre, University of Leicester, Glenfield Hospital, Leicester, UK.
• ⁴⁵ Department of Neurology, University of California at San Francisco, San Francisco, CA, USA.
• ⁴⁶ Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA, USA.
• ⁴⁷ Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
• ⁴⁸ Institute for Human Genetics, University of California, San Francisco, CA, USA.
• ⁴⁹ Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
• ⁵⁰ UK National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK.
• ⁵¹ Division of Research, Kaiser Permanente of Northern California, Oakland, CA, USA.
• ⁵² Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
• ⁵³ Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-University, Munich, Germany.
• ⁵⁴ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
• ⁵⁵ Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Munich, Germany.
• ⁵⁶ INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
• ⁵⁷ Department of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France.
• ⁵⁸ Department of Clinical Neuroscience at Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
• ⁵⁹ Institut Pasteur de Lille, UMR1167 LabEx DISTALZ - RID-AGE Université de Lille, INSERM, Centre Hospitalier Université de Lille Lille, Lille Lille, France.
• ⁶⁰ Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
• ⁶¹ Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
• ⁶² Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
• ⁶³ Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
• ⁶⁴ Neurosurgery NeuroCenter, Kuopio University Hospital, Kuopio, Finland.
• ⁶⁵ Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
• ⁶⁶ University of Cincinnati College of Medicine, Cincinnati, OH, USA.
• ⁶⁷ Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands. [email protected].