Validity of a CB-NAAT assay in diagnosing tuberculosis in comparison to culture: A study from an urban area of South India

Aishwarya Raj; Shrikala Baliga; M Suchitra Shenoy; B Dhanashree; P Prasanna Mithra; Smitha K Nambiar; Leesha Sharon

doi:10.1016/j.jctube.2020.100198

Validity of a CB-NAAT assay in diagnosing tuberculosis in comparison to culture: A study from an urban area of South India

J Clin Tuberc Other Mycobact Dis. 2020 Oct 28:21:100198. doi: 10.1016/j.jctube.2020.100198. eCollection 2020 Dec.

Authors

Aishwarya Raj¹, Shrikala Baliga^{2

3}, M Suchitra Shenoy^{2

3}, B Dhanashree^{2

3}, P Prasanna Mithra⁴, Smitha K Nambiar², Leesha Sharon²

Affiliations

¹ Department of Biophysics, National Institute of Mental Health and Neuro Sciences (Institute of National Importance), Bengaluru, India.
² Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.
³ Manipal McGill Centre for Infectious Diseases, PSPH, Manipal, India.
⁴ Department of Community Medicine, Kasturba Medical College, Mangalore, India.

Abstract

•CB-NAAT performance compared in 831 suspected pulmonary and extrapulmonary suspected cases.•The conventional stained smear and CB-NAAT results were compared to the MGIT culture.•Sensitivity and specificity of CB-NAAT was 84.43% and 94.93%.•The rapid results from CB-NAAT confirms its use in the tuberculosis diagnostic algorithm.•The benefits of disease diagnosis and prevention outweighs the price tag of the CB-NAAT tests.•This is more so for the resource poor countries where the burden of the disease is high.