Senescence Inflames the Pancreatic Tumor Microenvironment

Giulia Petroni; Lorenzo Galluzzi

doi:10.1016/j.xcrm.2020.100020

Senescence Inflames the Pancreatic Tumor Microenvironment

Cell Rep Med. 2020 May 19;1(2):100020. doi: 10.1016/j.xcrm.2020.100020.

Authors

Giulia Petroni¹, Lorenzo Galluzzi^{1

2

3

4

5}

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
² Sandra and Edward Meyer Cancer Center, New York, NY, USA.
³ Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.
⁴ Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
⁵ Université de Paris, Paris, France.

Abstract

Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators¹ have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8⁺ T cells.

Publication types

News
Comment

MeSH terms

CD8-Positive T-Lymphocytes
Carcinoma, Pancreatic Ductal*
Humans
Immunotherapy
Pancreatic Neoplasms* / drug therapy
Tumor Microenvironment