Leveraging Zebrafish To Study Bona Fide Astrocytes

Carmen Muñoz-Ballester; Robyn A Umans; Stefanie Robel

doi:10.1016/j.tins.2020.10.013

Leveraging Zebrafish To Study Bona Fide Astrocytes

Trends Neurosci. 2021 Feb;44(2):77-79. doi: 10.1016/j.tins.2020.10.013. Epub 2020 Nov 16.

Authors

Carmen Muñoz-Ballester¹, Robyn A Umans¹, Stefanie Robel²

Affiliations

¹ Center for Glial Biology in Health, Disease, and Cancer, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016, USA.
² Center for Glial Biology in Health, Disease, and Cancer, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA 24016, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: [email protected].

PMID: 33213859
DOI: 10.1016/j.tins.2020.10.013

Abstract

In a recent study, Chen and colleagues demonstrated that zebrafish spinal cord radial glia differentiate into cells that are similar to mammalian astrocytes. This study highlights the validity of the zebrafish model for discovering molecular mechanisms governing astrocyte function.

Keywords: astrocyte; development; evo-devo; evolution; fgf3; morphogenesis; radial glia; zebrafish.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Astrocytes*
Morphogenesis
Spinal Cord
Zebrafish Proteins
Zebrafish*

Substances

Zebrafish Proteins

Grants and funding

R01 NS105807/NS/NINDS NIH HHS/United States