Are redox changes a critical switch for mitotic progression?

Daniel C Lim; Vladimir Joukov; Michael B Yaffe

doi:10.1080/23723556.2020.1832419

Are redox changes a critical switch for mitotic progression?

Mol Cell Oncol. 2020 Oct 23;7(6):1832419. doi: 10.1080/23723556.2020.1832419.

Authors

Daniel C Lim¹, Vladimir Joukov², Michael B Yaffe^{1

3}

Affiliations

¹ MIT Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
² Department of Molecular Oncology, N. N. Petrov National Medical Research Center of Oncology, Saint Petersburg, 197758, Russian Federation.
³ Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Abstract

Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.

Keywords: AURKA; kinase activation; mitosis; mitotic kinase; redox regulation.

Abstract

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