Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.
Keywords: allergy; antibiotic; surgical prophylaxis; β-lactam.
Published by Oxford University Press for the Infectious Diseases Society of America 2020.