Supramolecular linear coordination polymers of human serum albumin and haemoglobin

Ryo Adachi; Shun Suzuki; Tatsuya Mitsuda; Yoshitsugu Morita; Teruyuki Komatsu

doi:10.1039/d0cc07167f

Supramolecular linear coordination polymers of human serum albumin and haemoglobin

Chem Commun (Camb). 2020 Dec 25;56(99):15585-15588. doi: 10.1039/d0cc07167f. Epub 2020 Nov 27.

Authors

Ryo Adachi¹, Shun Suzuki, Tatsuya Mitsuda, Yoshitsugu Morita, Teruyuki Komatsu

Affiliation

¹ Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. [email protected].

PMID: 33245310
DOI: 10.1039/d0cc07167f

Abstract

We describe the synthesis, structure, and functionalities of water-soluble linear coordination polymers of human serum albumin and haemoglobin, which are connected via a bis(terpyridyl)-Fe²⁺ complex. These protein fibres were self-assembled by lyophilisation and were transformed into single-wall nanotubes. The biological activities of the protein units were perfectly preserved in the long fibres.

MeSH terms

Hemoglobins / chemistry*
Hemoglobins / metabolism
Humans
Macromolecular Substances / chemical synthesis
Macromolecular Substances / chemistry
Macromolecular Substances / metabolism
Models, Molecular
Molecular Structure
Nanotubes / chemistry
Particle Size
Polymers / chemistry*
Polymers / metabolism
Serum Albumin, Human / chemistry*
Serum Albumin, Human / metabolism

Substances

Hemoglobins
Macromolecular Substances
Polymers
Serum Albumin, Human