Association between SARS-CoV-2 infection and Kawasaki-like multisystem inflammatory syndrome: a retrospective matched case-control study, Paris, France, April to May 2020

Euro Surveill. 2020 Dec;25(48):2001813. doi: 10.2807/1560-7917.ES.2020.25.48.2001813.

Abstract

We assessed the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Kawasaki disease (KD)-like multisystem inflammatory syndrome in a retrospective case-control study in France. RT-PCR and serological tests revealed SARS-CoV-2 infection in 17/23 cases vs 11/102 controls (matched odds ratio: 26.4; 95% confidence interval: 6.0-116.9), indicating strong association between SARS-CoV-2 infection and KD-like illness. Clinicians should keep a high level of suspicion for KD-like illness during the COVID-19 pandemic.

Keywords: COVID-19; Kawasaki-like disease; MIS-C; PIMS-TS; SARS-CoV-2.

MeSH terms

  • COVID-19*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Coronavirus / genetics*
  • Coronavirus / isolation & purification
  • Coronavirus Infections / diagnosis*
  • France / epidemiology
  • Humans
  • Mucocutaneous Lymph Node Syndrome / complications
  • Mucocutaneous Lymph Node Syndrome / virology*
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / epidemiology
  • Retrospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • Systemic Inflammatory Response Syndrome*

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related