Lipoprotein Lipase and Its Regulators: An Unfolding Story

Trends Endocrinol Metab. 2021 Jan;32(1):48-61. doi: 10.1016/j.tem.2020.11.005. Epub 2020 Dec 1.

Abstract

Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the 1940s, its biology and pathophysiological significance have been well characterized. Nonetheless, several studies in the past decade, with recent delineation of LPL crystal structure and the discovery of several new regulators such as angiopoietin-like proteins (ANGPTLs), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1) and Sel-1 suppressor of Lin-12-like 1 (SEL1L), have completely transformed our understanding of LPL biology.

Keywords: ANGPTL; GPIHBP1; LMF1; LPL; SEL1L; endoplasmic reticulum; endothelium; hyperlipidemia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Hyperlipidemias / metabolism
  • Lipoprotein Lipase / genetics
  • Lipoprotein Lipase / metabolism*
  • Receptors, Lipoprotein / genetics
  • Receptors, Lipoprotein / metabolism*
  • Triglycerides / metabolism

Substances

  • Receptors, Lipoprotein
  • Triglycerides
  • Lipoprotein Lipase