Interstitial lung opacities in patients with severe COVID-19 pneumonia by bedside high-resolution ultrasound in association to CO2 retention

Clin Hemorheol Microcirc. 2021;77(4):355-365. doi: 10.3233/CH-200925.

Abstract

Background: Coronavirus disease 2019 (COVID-19) can cause acute respiratory distress syndrome (ARDS).

Objective: This single centre cross-section study aimed to grade the severity of pneumonia by bed-side lung ultrasound (LUS).

Methods: A scoring system discriminates 5 levels of lung opacities: A-lines (0 points),≥3 B-line (1 point), coalescent B-lines (2 points), marked pleural disruptions (3 points), consolidations (4 points). LUS (convex 1-5 MHz probe) was performed at 6 defined regions for each hemithorax either in supine or prone position. A lung aeration score (LAS, maximum 4 points) was allocated for each patient by calculating the arithmetic mean of the examined lung areas. Score levels were correlated with ventilation parameters and laboratory markers.

Results: LAS of 20 patients with ARDS reached from 2.58 to 3.83 and was highest in the lateral right lobe (Mean 3.67). Ferritin levels (Mean 1885μg/l; r = 0.467; p = 0.051) showed moderate correlation in spearman roh calculation. PaCO2 level (Mean 46.75 mmHg; r = 0.632; p = 0.005) correlated significantly with LAS, while duration of ventilation, Horovitz index, CRP, LDH and IL-6 did not.

Concusions: The proposed LAS describes severity of lung opacities in COVID-19 patients and correlates with CO2 retention in patients with ARDS.

Keywords: COVID-19; PaCO2; lung ultrasound; scoring system.

MeSH terms

  • Adult
  • Aged
  • COVID-19 / diagnostic imaging*
  • COVID-19 / metabolism*
  • Carbon Dioxide / metabolism*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lung Diseases, Interstitial / diagnostic imaging
  • Lung Diseases, Interstitial / metabolism
  • Lung Diseases, Interstitial / virology
  • Male
  • Middle Aged
  • SARS-CoV-2 / isolation & purification
  • Ultrasonography / methods

Substances

  • Carbon Dioxide