One-pot preparation of a multi-functional enzymatically generated gelatin hydrogel with controllable antibacterial and hemorheological properties

Xing Zhu; Ting Gan; Xuechuan Wang; Yuanyuan Wang; Huijie Zhang; Qingxin Han

doi:10.1016/j.ijbiomac.2020.11.213

One-pot preparation of a multi-functional enzymatically generated gelatin hydrogel with controllable antibacterial and hemorheological properties

Int J Biol Macromol. 2021 Jan 31:168:143-151. doi: 10.1016/j.ijbiomac.2020.11.213. Epub 2020 Dec 9.

Authors

Xing Zhu¹, Ting Gan², Xuechuan Wang³, Yuanyuan Wang², Huijie Zhang², Qingxin Han¹

Affiliations

¹ College of Bioresources Chemical and Materials Engineering, Institute of Biomass & Functional Materials, Shaanxi University of Science & Technology, Weiyang District, Xi'an 710021, Shaanxi, China; The Youth Innovation Team of Shaanxi Universities, Xi'an 710021, Shaanxi, China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an 710021, Shaanxi, China.
² College of Bioresources Chemical and Materials Engineering, Institute of Biomass & Functional Materials, Shaanxi University of Science & Technology, Weiyang District, Xi'an 710021, Shaanxi, China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an 710021, Shaanxi, China.
³ College of Bioresources Chemical and Materials Engineering, Institute of Biomass & Functional Materials, Shaanxi University of Science & Technology, Weiyang District, Xi'an 710021, Shaanxi, China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an 710021, Shaanxi, China. Electronic address: [email protected].

PMID: 33309664
DOI: 10.1016/j.ijbiomac.2020.11.213

Abstract

The creation of multi-functional bio-hydrogels with tunable properties that meet in vivo demands is significant but remains challenging. Inspired by host-guest chemistry, a novel multi-functional gelatin-based bio-hydrogel with tunable antibacterial and hemorheological properties (TAH-GEL) is synthesized via an in situ one-pot strategy. TAH-GEL not only exhibits excellent mechanical properties but also shows promising self-healing and bio-compatibility features. For the first time, this biomaterial presents controllable antibacterial and hemorheological properties by controlling the TAH-GEL polypseudorotaxane motif. The resulting bio-hydrogel is easy to prepare and delivers superior performance, making it a powerful tool for bio-applications, such as hemostatic materials.

Keywords: Antibacterial; Gelatin hydrogel; Hemorheological; Multi-functional.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Biocompatible Materials / chemistry
Gelatin / chemical synthesis*
Gelatin / pharmacology*
Hemorrhage / drug therapy
Hydrogels / chemical synthesis*
Hydrogels / pharmacology

Substances

Anti-Bacterial Agents
Biocompatible Materials
Hydrogels
Gelatin