Assessing the relationship between institutional cancer and diabetes mortality rates using National Death Index data

Nina J Karlin; Matthew R Buras; Heidi E Kosiorek; Kyle E Coppola; Patricia M Verona; Curtiss B Cook

doi:10.2144/fsoa-2020-0055

Assessing the relationship between institutional cancer and diabetes mortality rates using National Death Index data

Future Sci OA. 2020 Oct 20;6(10):FSO633. doi: 10.2144/fsoa-2020-0055.

Authors

Nina J Karlin^{1

2}, Matthew R Buras³, Heidi E Kosiorek³, Kyle E Coppola², Patricia M Verona⁴, Curtiss B Cook⁵

Affiliations

¹ Division of Hematology & Medical Oncology, Mayo Clinic Hospital, Phoenix, AZ 85054, USA.
² Mayo Clinic Cancer Center, Scottsdale, AZ 85259, USA.
³ Biostatistics, Mayo Clinic, Scottsdale, AZ 85259, USA.
⁴ Department of Information Technology, Mayo Clinic Hospital, Phoenix, AZ 85054, USA.
⁵ Division of Endocrinology, Mayo Clinic, Scottsdale, AZ 85259, USA.

Abstract

Aim: To evaluate overall survival (OS), glycemic control in cancer patients with and without diabetes mellitus (DM).

Patients & methods: Patients (2010-2015) with newly diagnosed prostate, breast, lung, colorectal and pancreatic cancers were identified in institutional cancer registry. Data linked to National Death Index for vital status. 5-year OS estimated; glucose and hemoglobin A_1c assessed during year postdiagnosis.

Results: We identified 1404 patients (non-DM, n = 936; DM, n = 468). DM cohort had 168 deaths (36%); non-DM, 267 (29%). 5-year OS estimated at 58% (95% CI: 53-64%) for DM and 67% (95% CI: 64-71%) for controls; for matched pairs, hazard ratio: 1.35 (95% CI: 1.02-1.79). Cancer did not harm glycemic control.

Conclusion: OS among cancer patients with DM was lower than without DM.

Keywords: cancer; endocrinology; outcomes research.