1 School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
2 Southampton NIHR Respiratory Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
3 Department of Otorhinolaryngology / Head & Neck Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
4 NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
5 Faculty of Environmental & Life Sciences, Department of Biological Sciences, University of Southampton, Southampton, UK.