Nephrotic range proteinuria associated with focal segmental glomerulosclerosis reversed with pioglitazone therapy in a patient with Dunnigan type lipodystrophy

Diabetes Res Clin Pract. 2021 Feb:172:108620. doi: 10.1016/j.diabres.2020.108620. Epub 2020 Dec 13.

Abstract

Familial partiallipodystrophy (FPLD)is a rare disorder associated withsevere insulin resistance, hypertriglyceridemia, lowserumHDLcholesterol and proteinuricrenaldisease. Although proteinuric renal disease is not common among in patients with partial lipodystrophy, we report a patient with Dunnigan type FPLD complicated by nephrotic syndrome which resolved following treatment with thePPARγagonist pioglitazone, CPAP, diet, and exercise.

Keywords: Diabetes mellitus; Diabetic proteinuria; Focalsegmentalglomerulosclerosis; Lipodystrophy syndrome; Pioglitazone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Glomerulosclerosis, Focal Segmental / complications*
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / etiology
  • Lipodystrophy / physiopathology*
  • Pioglitazone / therapeutic use*
  • Prognosis
  • Proteinuria / drug therapy*
  • Proteinuria / etiology

Substances

  • Hypoglycemic Agents
  • Pioglitazone