Resolving the Instructions for αβ T Cell Development

Immunity. 2020 Dec 15;53(6):1126-1128. doi: 10.1016/j.immuni.2020.11.014.

Abstract

In this issue of Immunity, Chopp et. al. use single-cell transcriptomics and epigenomics in mice and human samples to delineate developmental trajectories of αβ T cell subsets and refine the kinetic selection model of CD4+ and CD8+ T cell lineage commitment.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Epigenomics
  • Humans
  • Mice
  • Receptors, Antigen, T-Cell, alpha-beta* / genetics
  • Receptors, Antigen, T-Cell, gamma-delta* / genetics
  • T-Lymphocyte Subsets
  • Transcriptome

Substances

  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta