A Survey of Synthetic Routes and Antitumor Activities for Benzo[ g]quinoxaline-5,10-diones

Molecules. 2020 Dec 14;25(24):5922. doi: 10.3390/molecules25245922.

Abstract

Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties.

Keywords: 1,4-diazaanthraquinone; anthracene-9,10-dione; benzo[g]quinoxaline-5,10-dione.

Publication types

  • Review

MeSH terms

  • Anthraquinones / chemical synthesis*
  • Anthraquinones / pharmacology
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Chemistry Techniques, Synthetic*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Inhibitory Concentration 50
  • Neoplasms / drug therapy
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Quinoxalines / chemical synthesis*
  • Quinoxalines / pharmacology
  • Structure-Activity Relationship
  • Topoisomerase Inhibitors / chemical synthesis*
  • Topoisomerase Inhibitors / pharmacology
  • Tumor Suppressor Protein p53 / agonists
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Anthraquinones
  • Antineoplastic Agents
  • Quinoxalines
  • Topoisomerase Inhibitors
  • Tumor Suppressor Protein p53