Genomic characteristics of listeria monocytogenes causing invasive listeriosis in Japan

Diagn Microbiol Infect Dis. 2021 Mar;99(3):115233. doi: 10.1016/j.diagmicrobio.2020.115233. Epub 2020 Oct 6.

Abstract

We reviewed 18 listeriosis cases in Japan and performed molecular analysis of causative Listeria monocytogenes (LM) isolates. Strains genetically related to those from other countries caused various types of listeriosis, including vascular listeriosis in immunocompetent elderly people. Our results highlight the importance of integrated clinical and genomic analysis of LM.

Keywords: International transmission; Listeria monocytogenes; Vascular listeriosis; Virulence genes; Whole-genome sequencing.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Bacterial Proteins / genetics
  • Female
  • Genome, Bacterial*
  • Genomics
  • Humans
  • Infant
  • Japan / epidemiology
  • Listeria monocytogenes / genetics*
  • Listeria monocytogenes / pathogenicity*
  • Listeriosis / blood
  • Listeriosis / epidemiology*
  • Listeriosis / transmission
  • Male
  • Virulence Factors / genetics*
  • Whole Genome Sequencing

Substances

  • Bacterial Proteins
  • Virulence Factors