Molecular analysis of a rare case of low-grade primary peritoneal serous carcinoma in a male

Vladislav V Makarenko; Dina Kandil; Ediz F Cosar; Lloyd Hutchinson; Ashraf Khan

doi:10.1177/2036361320979219

Molecular analysis of a rare case of low-grade primary peritoneal serous carcinoma in a male

Rare Tumors. 2020 Dec 9:12:2036361320979219. doi: 10.1177/2036361320979219. eCollection 2020.

Authors

Vladislav V Makarenko^{1

2}, Dina Kandil¹, Ediz F Cosar¹, Lloyd Hutchinson¹, Ashraf Khan^{1

3}

Affiliations

¹ Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA.
² Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
³ Department of Pathology, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.

Abstract

Primary peritoneal serous carcinomas (PPSC) are exceedingly rare in male patients. Only a few cases were reported, and mostly with the limited immunophenotypical characterization. No molecular analysis of PPSC in males has been previously performed. We here describe another case of PPSC in a male patient. A comprehensive molecular analysis of the tumor revealed SF3B1 gene mutation as a possible driver.

Keywords: Low-grade primary peritoneal serous carcinoma; male; molecular analysis.

Publication types

Case Reports