The Jekyll and Hyde of Senescence in Cancer: TIMP1 Controls the Switch from Tumor-Controlling to Tumor-Promoting Senescence

Sabela Da Silva-Álvarez; Manuel Collado

doi:10.1016/j.ccell.2020.12.013

The Jekyll and Hyde of Senescence in Cancer: TIMP1 Controls the Switch from Tumor-Controlling to Tumor-Promoting Senescence

Cancer Cell. 2021 Jan 11;39(1):13-15. doi: 10.1016/j.ccell.2020.12.013. Epub 2020 Dec 24.

Authors

Sabela Da Silva-Álvarez¹, Manuel Collado²

Affiliations

¹ Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), E15706 Santiago de Compostela, Spain.
² Laboratory of Stem Cells in Cancer and Aging, Health Research Institute of Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), E15706 Santiago de Compostela, Spain. Electronic address: [email protected].

PMID: 33357453
DOI: 10.1016/j.ccell.2020.12.013

Abstract

Cellular senescence is a response with two faces in cancer: it restricts tumor proliferation, but it can also promote cancer progression and metastasis. In this issue of Cancer Cell, Guccini et al. uncover the role of TIMP1 in prostate cancer allowing a switch from tumor-controlling to tumor-promoting senescence.

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MeSH terms

Cellular Senescence / genetics
Humans
Male
Prostatic Neoplasms* / genetics
Tissue Inhibitor of Metalloproteinase-1

Substances

TIMP1 protein, human
Tissue Inhibitor of Metalloproteinase-1