Donor cell-derived chronic myelomonocytic leukemia presenting after allogeneic hematopoietic cell transplantation for T-cell acute lymphoblastic leukemia

Kevin C Miller; Zaid H Abdel Rahman; Ryan S Robetorye; James M Foran

doi:10.1002/ccr3.3383

Donor cell-derived chronic myelomonocytic leukemia presenting after allogeneic hematopoietic cell transplantation for T-cell acute lymphoblastic leukemia

Clin Case Rep. 2020 Oct 7;8(12):3225-3228. doi: 10.1002/ccr3.3383. eCollection 2020 Dec.

Authors

Kevin C Miller¹, Zaid H Abdel Rahman², Ryan S Robetorye³, James M Foran²

Affiliations

¹ Department of Medicine Massachusetts General Hospital Boston MA USA.
² Division of Hematology/Oncology Mayo Clinic Jacksonville FL USA.
³ Department of Laboratory Medicine and Pathology Mayo Clinic Phoenix AZ USA.

Abstract

Donor cell leukemia is a very rare cause of relapse after allogeneic hematopoietic cell transplantation (alloHCT). Herein, we describe an unprecedented case of donor cell-derived chronic myelomonocytic leukemia (CMML) presenting seven years after a 51-year-old man received a matched-related alloHCT from his 59-year-old brother for T-cell acute lymphoblastic leukemia.

Keywords: CMML; allogeneic hematopoietic cell transplant; chronic myelomonocytic leukemia; donor cell leukemia; stem cell transplant.

Publication types

Case Reports