Serum pentosidine levels in systemic lupus erythematosus

Renato Nisihara; Thelma Skare; Vanessa F Picceli; Altair Ambrosio; Carolina Ferreira; Fernanda Baracho; Iara Messias-Reason

doi:10.1016/j.plabm.2020.e00197

Serum pentosidine levels in systemic lupus erythematosus

Pract Lab Med. 2020 Dec 19:23:e00197. doi: 10.1016/j.plabm.2020.e00197. eCollection 2021 Jan.

Authors

Renato Nisihara^{1

2}, Thelma Skare¹, Vanessa F Picceli¹, Altair Ambrosio^{3

2}, Carolina Ferreira¹, Fernanda Baracho¹, Iara Messias-Reason³

Affiliations

¹ Mackenzie Evangelical School of Medicine Paraná, Brazil.
² Department of Medicine, Positivo University, Curitiba, Brazil.
³ Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.

Abstract

Background: Chronic inflammatory diseases lead to glycation of protein, lipids and nuclear acids. One product generated in this context is pentosidine.

Aim: To study pentosidine levels in Systemic Lupus Erythematosus (SLE) and its possible association with disease activity and cumulative damage.

Methods: Pentosidine serum levels were measured in the serum by ELISA commercial kits in 79 patients with SLE. Disease activity index and cumulative damage were studied by SELENA-SLEDAI (Safety of Estrogen in Lupus National Assessment Systemic Lupus Erythematosus Disease Activity Index) and cumulative damage by SLICC/ACR DI (Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for Systemic Lupus Erythematosus) respectively and simultaneously with determination of pentosidine levels. Epidemiological and clinical and serological profile were collected from the charts.

Results: In the 79 studied patients, the SLEDAI ranged from 0 to 12 (median of 0) and the SLICC/ACR-DI from 0 to 4 (median of 0). Serum pentosidine levels did not correlate with SLEDAI neither with SLICC. Patients with discoid skin lesions and photosensitivity had lower levels than those without them, with p = 0.04 in both.

Conclusion: In SLE, serum pentosidine levels did not reflect activity and cumulative damage. Patients with skin manifestations had lower levels of this biomarker.

Keywords: Disease activity; Lupus; Pentosidine.