Rationale: Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor derived from follicular dendritic cells, and is often associated with Castleman disease. Here we present a rare case of paraneoplastic pemphigus (PNP) with FDCS which required multidisciplinary approach for the diagnosis and treatment.
Patient concerns: A 28-year-old Chinese female had FDCS recurrence, and primary clinical manifestation was PNP.
Diagnoses: PNP with FDCS.
Interventions: The patient received gamma globulin infusion, took anlotinib, and underwent plasma exchange therapy.
Outcomes: The skin lesions recovered and there was no evidence of tumor recurrence.
Lessons: The diagnosis and management of PNP with FDCS require close cooperation among surgeons, dermatologists, hematologists, otolaryngologists, oncologists, radiologists, pathologists, and respiratory doctors. The interesting clinical manifestations of this patient provide a multifaceted approach to the investigation of the interactions among FDCS, Castleman disease, and PNP.
Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.