Normal pregnancy and delivery two years after adjuvant chemotherapy for grade III immature ovarian teratoma

Gynecol Oncol. 1988 Feb;29(2):245-9. doi: 10.1016/0090-8258(88)90220-x.

Abstract

A 27-year-old woman with grade 3 immature teratoma of the ovary was treated with unilateral salpingo-oophorectomy and VAC combination chemotherapy. She received 6 postoperative courses, although initially 12 were planned. Chemotherapy had to be discontinued because of severe bone marrow toxicity. Eighteen months later the patient became pregnant and was ultimately delivered of a normal child. This is the second report of a successful pregnancy following VAC chemotherapy for immature teratoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Cyclophosphamide / administration & dosage
  • Dactinomycin / administration & dosage
  • Delivery, Obstetric
  • Female
  • Humans
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Pregnancy*
  • Teratoma / drug therapy*
  • Teratoma / pathology
  • Teratoma / surgery
  • Time Factors
  • Vincristine / administration & dosage

Substances

  • Dactinomycin
  • Vincristine
  • Cyclophosphamide

Supplementary concepts

  • VAC protocol