Monitoring acid base status in CKD patients: can urinary citrate help?

Kidney Int. 2021 Jan;99(1):28-31. doi: 10.1016/j.kint.2020.09.023.

Abstract

Metabolic acidosis is an early and deleterious complication of chronic kidney disease. Because it is frequently eubicarbonatemic, diagnosis may be difficult. In this issue, Gianella et al. suggest that lower urinary citrate excretion, considered as an homeostatic response to metabolic acidosis, may be helpful for early diagnosis and monitoring of alkali treatment. This study should be an incentive for further assessment of the tubular handling of urinary citrate in CKD patients and determination of the performance of urinary citrate for the diagnosis of eubicarbonatemic metabolic acidosis and monitoring of alkali therapy.

Publication types

  • Comment

MeSH terms

  • Acidosis* / diagnosis
  • Acidosis* / etiology
  • Citrates
  • Citric Acid
  • Creatinine
  • Humans
  • Renal Insufficiency, Chronic* / diagnosis
  • Renal Insufficiency, Chronic* / therapy

Substances

  • Citrates
  • Citric Acid
  • Creatinine