Abstract
A mild Rh-catalyzed method for synthesis of cyclic unprotected N-Me and N-H 2,3-aminoethers using an olefin aziridination-aziridine ring-opening domino reaction has been developed. The method is readily applicable to the stereocontrolled synthesis of a variety of 2,3-disubstituted aminoether O-heterocyclic scaffolds, including tetrahydrofurans, tetrahydropyrans and chromanes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Chemistry Techniques, Synthetic
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Ethers / chemistry*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry*
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Hydrogen / chemistry
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Nitrogen / chemistry*
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Stereoisomerism
Substances
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Ethers
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Heterocyclic Compounds
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Hydrogen
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Nitrogen