Ruxolitinib discontinuation syndrome: incidence, risk factors, and management in 251 patients with myelofibrosis

Francesca Palandri; Giuseppe Alberto Palumbo; Elena Maria Elli; Nicola Polverelli; Giulia Benevolo; Bruno Martino; Elisabetta Abruzzese; Mario Tiribelli; Alessia Tieghi; Roberto Latagliata; Francesco Cavazzini; Micaela Bergamaschi; Gianni Binotto; Monica Crugnola; Alessandro Isidori; Giovanni Caocci; Florian Heidel; Novella Pugliese; Costanza Bosi; Daniela Bartoletti; Giuseppe Auteri; Daniele Cattaneo; Luigi Scaffidi; Malgorzata Monica Trawinska; Rossella Stella; Fiorella Ciantia; Fabrizio Pane; Antonio Cuneo; Mauro Krampera; Gianpietro Semenzato; Roberto Massimo Lemoli; Alessandra Iurlo; Nicola Vianelli; Michele Cavo; Massimo Breccia; Massimiliano Bonifacio

doi:10.1038/s41408-020-00392-1

Ruxolitinib discontinuation syndrome: incidence, risk factors, and management in 251 patients with myelofibrosis

Blood Cancer J. 2021 Jan 7;11(1):4. doi: 10.1038/s41408-020-00392-1.

Authors

Francesca Palandri¹, Giuseppe Alberto Palumbo², Elena Maria Elli³, Nicola Polverelli⁴, Giulia Benevolo⁵, Bruno Martino⁶, Elisabetta Abruzzese⁷, Mario Tiribelli⁸, Alessia Tieghi⁹, Roberto Latagliata¹⁰, Francesco Cavazzini¹¹, Micaela Bergamaschi¹², Gianni Binotto¹³, Monica Crugnola¹⁴, Alessandro Isidori¹⁵, Giovanni Caocci¹⁶, Florian Heidel¹⁷, Novella Pugliese¹⁸, Costanza Bosi¹⁹, Daniela Bartoletti²⁰, Giuseppe Auteri²⁰, Daniele Cattaneo²¹, Luigi Scaffidi²², Malgorzata Monica Trawinska⁷, Rossella Stella⁸, Fiorella Ciantia²³, Fabrizio Pane¹⁸, Antonio Cuneo¹¹, Mauro Krampera²², Gianpietro Semenzato¹³, Roberto Massimo Lemoli¹², Alessandra Iurlo²¹, Nicola Vianelli²⁰, Michele Cavo²⁰, Massimo Breccia¹⁰, Massimiliano Bonifacio²²

Affiliations

¹ Azienda Ospedaliero-Universitaria di Bologna, IRCCS Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico S.Orsola-Malpighi, Dipartimento di Oncologia e di Ematologia, Bologna, Italia. [email protected].
² Department of Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F. Ingrassia", University of Catania, Catania, Italy.
³ Hematology Division, San Gerardo Hospital, ASST Monza, Monza, Italy.
⁴ Unit of Blood Diseases and Stem Cells Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy.
⁵ Division of Hematology, Città della Salute e della Scienza Hospital, Torino, Italy.
⁶ Division of Hematology, Azienda Ospedaliera 'Bianchi Melacrino Morelli', Reggio Calabria, Italy.
⁷ Division of Hematology, Ospedale S. Eugenio, Roma, Italy.
⁸ Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy.
⁹ Department of Hematology, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
¹⁰ Division of Cellular Biotechnologies and Hematology, University Sapienza, Roma, Italy.
¹¹ Division of Hematology, University of Ferrara, Ferrara, Italy.
¹² Clinic of Hematology, Department of Internal Medicine (DiMI), IRCCS AOU San Martino-IST, Genova, Italy.
¹³ Unit of Hematology and Clinical Immunology, University of Padova, Padova, Italy.
¹⁴ Haematology and BMT Centre, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
¹⁵ Hematology and Stem Cell Transplant Center, AORMN Hospital, Pesaro, Italy.
¹⁶ Hematology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
¹⁷ Internal Medicine II, Hematology and Oncology, Friedrich-Schiller-University Medical Center, Jena, Germany.
¹⁸ Department of Medicine and Surgery, Hematology and Hematopoietic Stem Cell Transplant Center, University of Naples Federico II, Napoli, Italy.
¹⁹ Division of Hematology, AUSL di Piacenza, Piacenza, Italy.
²⁰ Azienda Ospedaliero-Universitaria di Bologna, IRCCS Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico S.Orsola-Malpighi, Dipartimento di Oncologia e di Ematologia, Bologna, Italia.
²¹ Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
²² Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.
²³ Division of Hematology, AOU Policlinico V. Emanuele, University of Catania, Catania, Italy.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Janus Kinases / antagonists & inhibitors
Multivariate Analysis
Nitriles
Primary Myelofibrosis / drug therapy*
Protein Kinase Inhibitors / administration & dosage
Protein Kinase Inhibitors / therapeutic use*
Pyrazoles / administration & dosage
Pyrazoles / therapeutic use*
Pyrimidines
Risk Factors
Treatment Outcome

Substances

Nitriles
Protein Kinase Inhibitors
Pyrazoles
Pyrimidines
ruxolitinib
Janus Kinases