Major publications in the critical care pharmacotherapy literature: 2019

Melanie Smith Condeni; Alyson T Basting; Patrick G Costello; Ashley DePriest; Evert A Eriksson; Heather Evans; Kristie Hertel; Andre L Holder; Alyssa N Kester; Kinsey R Kowalski; Carolyn Magee Bell; Barbara McLean; Michael Reichert; Melissa Santibañez; Patrick M Wieruszewski; Andrea Sikora Newsome

doi:10.1016/j.jcrc.2020.12.018

Major publications in the critical care pharmacotherapy literature: 2019

J Crit Care. 2021 Apr:62:197-205. doi: 10.1016/j.jcrc.2020.12.018. Epub 2020 Dec 27.

Authors

Melanie Smith Condeni¹, Alyson T Basting², Patrick G Costello³, Ashley DePriest⁴, Evert A Eriksson⁵, Heather Evans⁶, Kristie Hertel⁷, Andre L Holder⁸, Alyssa N Kester⁹, Kinsey R Kowalski¹⁰, Carolyn Magee Bell¹¹, Barbara McLean¹², Michael Reichert¹³, Melissa Santibañez¹⁴, Patrick M Wieruszewski¹⁵, Andrea Sikora Newsome¹⁶

Affiliations

¹ Medical University of South Carolina, 150 Ashley Avenue, Charleston, SC 29425, USA. Electronic address: [email protected].
² Indiana University Health Arnett Hospital, 5165 McCarty Ln, Lafayette, IN 47905, USA. Electronic address: [email protected].
³ University of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. Electronic address: [email protected].
⁴ Wellstar Kennestone Regional Medical Center, 677 Church Street, Marietta, GA 30060, USA. Electronic address: [email protected].
⁵ Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA. Electronic address: [email protected].
⁶ Medical University of South Carolina, 96 Jonathan Lucas St, Room CSB 426, Charleston, SC 29425, USA. Electronic address: [email protected].
⁷ Vidant Medical Center, 2100 Stantonsburg Road, Greenville, NC 27831, USA.
⁸ Emory University School of Medicine, Grady Memorial Hospital, 80 Jesse Hill Jr Drive SE, Rm 2D012, Atlanta, GA 30303, USA. Electronic address: [email protected].
⁹ St. Luke's University Health Network, 801 Ostrum Street, Bethlehem, PA 18015, USA. Electronic address: [email protected].
¹⁰ Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Electronic address: [email protected].
¹¹ Medical University of South Carolina, 150 Ashley Ave MSC 584, Charleston, SC 29425, USA. Electronic address: [email protected].
¹² Grady Health Systems, Atlanta, GA 30303, USA.
¹³ Emory Hillandale Hospital, 2801 Dekalb Medical Parkway, Lithonia, GA 30058, USA.
¹⁴ Larkin University, College of Pharmacy, 18301 North Miami Avenue, Miami, FL 33169, USA. Electronic address: [email protected].
¹⁵ Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: [email protected].
¹⁶ The University of Georgia College of Pharmacy, 1120 15(th) St, HM-118, Augusta, GA 30912, USA. Electronic address: [email protected].

Abstract

Purpose: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2019.

Materials and methods: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 36 journals monthly for impactful articles and reviewed 113 articles during 2019 according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria.

Results: Articles with a 1A grade, including three clinical practice guidelines, six meta-analyses, and five original research trials are reviewed here from those included in the monthly CCPLU. Clinical practice guidelines on the use of polymyxins and antiarrhythmic drugs in cardiac arrest as well as meta-analyses on antipsychotic use in delirium, stress ulcer prophylaxis (SUP), and vasoactive medications in septic shock and cardiac arrest were summarized. Original research trials evaluated delirium, sedation, neuromuscular blockade, SUP, anticoagulation reversal, and hemostasis.

Conclusion: This clinical review and expert opinion provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2019.

Keywords: Cardiac arrest; Critical care; Drug therapy; Guideline; Review; Septic shock.

Major publications in the critical care pharmacotherapy literature: 2019

Authors

Affiliations

Abstract

Publication types

MeSH terms

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