Similarities and differences between HIV and SARS-CoV-2

Int J Med Sci. 2021 Jan 1;18(3):846-851. doi: 10.7150/ijms.50133. eCollection 2021.

Abstract

In the last 50 years we have experienced two big pandemics, the HIV pandemic and the pandemic caused by SARS-CoV-2. Both pandemics are caused by RNA viruses and have reached us from animals. These two viruses are different in the transmission mode and in the symptoms they generate. However, they have important similarities: the fear in the population, increase in proinflammatory cytokines that generate intestinal microbiota modifications or NETosis production by polymorphonuclear neutrophils, among others. They have been implicated in the clinical, prognostic and therapeutic attitudes.

Keywords: AIDS; COVID-19; HIV; SARS-CoV-2; pandemics.

Publication types

  • Historical Article
  • Review

MeSH terms

  • COVID-19 / epidemiology*
  • COVID-19 / immunology
  • COVID-19 / psychology
  • COVID-19 / transmission
  • Cytokines / blood
  • Cytokines / immunology
  • Extracellular Traps / immunology
  • Extracellular Traps / metabolism
  • Fear
  • Global Burden of Disease / statistics & numerical data
  • HIV Infections / epidemiology*
  • HIV Infections / immunology
  • HIV Infections / psychology
  • HIV Infections / transmission
  • HIV-1 / immunology
  • HIV-1 / isolation & purification
  • HIV-1 / pathogenicity*
  • History, 20th Century
  • History, 21st Century
  • Host-Pathogen Interactions / immunology
  • Humans
  • Inflammation Mediators / blood
  • Inflammation Mediators / immunology
  • Mortality
  • Neutrophils / immunology
  • Neutrophils / metabolism
  • Pandemics / history*
  • Pandemics / statistics & numerical data
  • Prognosis
  • SARS-CoV-2 / immunology
  • SARS-CoV-2 / isolation & purification
  • SARS-CoV-2 / pathogenicity*

Substances

  • Cytokines
  • Inflammation Mediators